Fig. 2
Histology and immunohistochemistry of IOMM-Lee monolayer third-passage 2D model, xenograft (in vivo), and 3D model – Representative images. Both the in vivo and the 3D models were incubated for 13 days. H&E: Hematoxylin and Eosin, EMA: Epithelial membrane antigen, PR: Progesterone receptor, Ki-67: Proliferation, SSTR2: Somatostatin receptor 2, GFAP: Glial fibrillary acidic protein. Black scale bars: All histology slides: 100 \(\:{\upmu\:}\)m. The overview (OV) images represent 2D: overview of fibrin clots black bar: 2,5 mm. in vivo: Coronal slice of rat brain with white arrows pointing towards tumor, black scale bar: 2,5 mm. 3D: 3D brightfield, the circle is 1 mm in diameter – black scale bar represent 200 \(\:{\upmu\:}\text{m}\)