Table 3 P14 PCR results following 60s injuries. Statistical results from the two-way ANOVA for gene expression in the P14 HPC and PFC following 1, 3, 5, or Sham 60s injuries
Gene | ANOVA Results | ||
|---|---|---|---|
Sex | Injury | Interaction | |
HPC | |||
AQP4 | F(1,46) = 1.80 p = 0.19 | F(1,46) = 6.85 p = 0.01 0 > 5, p = 0.003 | F(1,46) = 0.01 p = 0.93 |
CNR1 | F(1,46) = 0.38 p = 0.54 | F(1,46) = 17.96 p < 0.001 0 < 1, p < 0.001 0 < 3, p < 0.001 0 < 5, p = 0.01 | F(1,46) = 0.04 p = 0.83 |
EfnB | F(1,46) = 0.64 p = 0.64 | F(1,46) = 12.75 p < 0.001 0 < 1, p = 0.003 0 < 3, p = 0.01 0 < 5, p = 0.01 | F(1,46) = 1.50 p = 0.23 |
Egr-1 | F(1,46) = 0.01 p = 0.92 | F(1,46) = 17.28 p < 0.001 0 < 1, p < 0.001 0 < 3, p < 0.001 0 < 5, p = 0.01 | F(1,46) = 0.01 p = 0.91 |
FOXP3 | F(1,46) = 0.27 p = 0.61 | F(1,46) = 8.49 p = 0.01 0 < 1, p = 0.002 0 < 3, p = 0.002 | F(1,46) = 0.62 p = 0.44 |
GABRA1 | F(1,46) = 5.31 p = 0.03 ♀>♂ | F(1,46) = 5.28 p = 0.03 | F(1,46) = 1.18 p = 0.09 |
GATA3 | F(1,46) = 1.59 p = 0.22 | F(1,46) = 20.02 p < 0.001 0 > 1, p = 0.001 0 > 3, p = 0.002 0 > 5, < 0.001 | F(1,46) = 0.02 p = 0.88 |
GFAP | F(1,46) = 6.45 p = 0.02 ♀>♂ | F(1,46) = 1.55 p = 0.22 | F(1,46) = 0.62 p = 0.43 |
GHRH | F(1,46) = 0.82 p = 0.37 | F(1,46) = 36.69 p < 0.001 0 > 1, p < 0.001 0 > 3, p < 0.001 0 > 5, p < 0.001 | F(1,46) = 0.79 p = 0.38 |
HSPA9 | F(1,46) = 2.63 p = 0.11 | F(1,46) = 4.20 p = 0.05 | F(1,46) = 0.23 p = 0.64 |
IGF-1 | F(1,46) = 0.31 p = 0.58 | F(1,46) = 4.20 p = 0.01 0 > 1, p = 0.01 0 > 3, p = 0.01 0 > 5, p = 0.004 | F(1,46) = 0.01 p = 0.99 |
MAOA | F(1,46) = 2.16 p = 0.15 | F(1,46) = 7.49 p = 0.01 0 > 5, p = 0.01 | F(1,46) = 1.18 p = 0.28 |
MapK | F(1,46) = 0.01 p = 0.92 | F(1,46) = 16.76 p < 0.001 0 < 1, p < 0.001 0 < 3, p < 0.001 0 < 5, p = 0.01 | F(1,46) = 0.01 p = 0.95 |
MBP | F(1,46) = 4.47 p = 0.04 ♀>♂ | F(1,46) = 0.18 p = 0.67 | F(1,46) = 0.60 p = 0.45 |
NfL | F(1,46) = 5.44 p = 0.03 ♀>♂ | F(1,46) = 7.42 p = 0.01 0 > 1, p = 0.05 0 > 5, p = 0.01 | F(1,46) = 0.33 p = 0.57 |
SOCS1 | F(1,46) = 0.01 p = 0.91 | F(1,46) = 7.68 p = 0.01 0 > 1, p = 0.03 0 > 5, p = 0.01 | F(1,46) = 0.01 p = 0.93 |
SYP | F(1,46) = 4.80 p = 0.03 ♀>♂ | F(1,46) = 0.02 p = 0.89 | F(1,46) = 0.25 p = 0.62 |
PFC | |||
Apaf-1 | F(1,46) = 0.30 p = 0.98 | F(1,46) = 4.41 p = 0.04 | F(1,46) = 0.52 p = 0.48 |
AQP4 | F(1,46) = 0.02 p = 0.90 | F(1,46) = 5.09 p = 0.03 | F(1,46) = 0.02 p = 0.89 |
CCL2 | F(1,46) = 0.002 p = 0.97 | F(1,46) = 3.89 p = 0.03 | F(1,46) = 0.60 p = 0.62 |
CNR1 | F(1,46) = 0.38 p = 0.55 | F(1,46) = 4.25 p = 0.004 0 < 1, p = 0.002 0 < 3, p = 0.01 0 < 5, p = 0.03 | F(1,46) = 0.91 p = 0.35 |
Egr-1 | F(1,46) = 7.33 p = 0.01 ♀>♂ | F(1,46) = 10.55 p = 0.002 0 < 1, p = 0.04 0 < 3, p = 0.04 0 < 5, p < 0.001 | F(1,46) = 1.88 p = 0.18 |
Eno2 | F(1,46) = 1.98 p = 0.17 | F(1,46) = 21.38 p < 0.001 0 < 1, p < 0.001 0 < 3, p < 0.001 0 < 5, p < 0.001 | F(1,46) = 1.04 p = 0.31 |
GFAP | F(1,46) = 0.20 p = 0.66 | F(1,46) = 4.83 p = 0.03 | F(1,46) = 0.06 p = 0.81 |
GHRH | F(1,46) = 2.71 p = 0.11 | F(1,46) = 5.11 p = 0.03 | F(1,46) = 3.96 p = 0.02 |
GSK3B | F(1,46) = 0.08 p = 0.78 | F(1,46) = 3.10 p = 0.04 | F(1,46) = 1.23 p = 0.31 |
HIF-1\(\:\alpha\:\) | F(1,46) = 1.34 p = 0.25 | F(1,46) = 6.60 p = 0.001 0 < 1, p < 0.001 0 < 3, p = 0.002 0 < 5, p < 0.001 | F(1,46) = 0.34 p = 0.80 |
Iba1 | F(1,46) = 0.06 p = 0.81 | F(1,46) = 6.74 p = 0.01 0 < 5, p = 0.01 | F(1,46) = 0.94 p = 0.34 |
IGF-1 | F(1,46) = 0.80 p = 0.38 | F(1,46) = 5.19 p = 0.03 | F(1,46) = 0.02 p = 0.89 |
IL-6 | F(1,46) = 0.50 p = 0.50 | F(1,46) = 8.18 p = 0.01 0 < 3, p = 0.04 0 < 5, p = 0.003 | F(1,46) = 2.29 p = 0.14 |
MapK | F(1,46) = 0.01 p = 0.94 | F(1,46) = 5.08 p = 0.01 0 < 1, p < 0.001 0 < 5, p = 0.01 | F(1,46) = 1.87 p = 0.15 |
MBP | F(1,46) = 0.84 p = 0.36 | F(1,46) = 14.76 p < 0.001 0 < 1, p = 0.02 0 < 3, p = 0.01 0 < 5, p < 0.001 | F(1,46) = 0.49 p = 0.49 |
MYRF | F(1,46) = 1.86 p = 0.18 | F(1,46) = 9.02 p = 0.004 0 < 1, p = 0.05 0 < 5, p < 0.001 | F(1,46) = 0.02 p = 0.90 |
NES | F(1,46) = 0.26 p = 0.61 | F(1,46) = 4.57 p = 0.04 | F(1,46) = 0.31 p = 0.58 |
NF-kB | F(1,46) = 0.63 p = 0.43 | F(1,46) = 4.26 p = 0.01 0 < 1, p = 0.03 0 < 5, p = 0.001 3 < 5, p = 0.04 | F(1,46) = 0.95 p = 0.43 |
NLRP3 | F(1,46) = 0.4.64 p = 0.04 ♀<♂ | F(1,46) = 5.31 p = 0.03 | F(1,46) = 0.50 p = 0.48 |
NOS2 | F(1,46) = 0.01 p = 0.94 | F(1,46) = 4.09 p = 0.05 | F(1,46) = 0.06 p = 0.80 |
NR3C1 | F(1,46) = 0.67 p = 0.42 | F(1,46) = 8.37 p = 0.01 0 < 1, p = 0.02 0 < 5, p = 0.003 | F(1,46) = 0.03 p = 0.87 |
SOCS1 | F(1,46) = 1.81 p = 0.19 | F(1,46) = 5.91 p = 0.02 | F(1,46) = 0.14 p = 0.71 |
STAT3 | F(1,46) = 0.004 p = 0.95 | F(1,46) = 5.11 p = 0.03 | F(1,46) = 0.56 p = 0.46 |
SYP | F(1,46) = 0.89 p = 0.35 | F(1,46) = 8.92 p = 0.005 0 < 1, p = 0.01 0 < 3, p = 0.02 0 < 5, p = 0.02 | F(1,46) = 0.60 p = 0.81 |
TMEM119 | F(1,46) = 0.03 p = 0.87 | F(1,46) = 4.67 p = 0.04 | F(1,46) = 3.26 p = 0.08 |
TREM2 | F(1,46) = 2.53 p = 0.12 | F(1,46) = 12.76 p < 0.001 0 < 1, p = 0.02 0 < 3, p = 0.03 0 < 5, p < 0.001 | F(1,46) = 0.40 p = 0.53 |
VCAM1 | F(1,46) = 0.25 p = 0.62 | F(1,46) = 5.45 p = 0.02 | F(1,46) = 1.95 p = 0.17 |
VEGF-A | F(1,46) = 0.003 p = 0.96 | F(1,46) = 5.69 p = 0.02 | F(1,46) = 0.74 p = 0.40 |