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Table 2 P21 PCR results following 15s injuries. Statistical results from the two-way ANOVA for gene expression in the HPC and PFC following 1, 3 or sham 15s injuries

From: Shaking into deficits: investigating behavioural and neuropathological outcomes associated with a novel preclinical model of infant abusive head trauma

Gene

ANOVA Results

Sex

Injury

Interaction

HPC

VEGF-A

F(1,22) = 0.04

p = 0.84

F(2,22) = 10.56

p = 0.001

0 > 3, p = 0.004

1 > 3, p < 0.001

F(2,22) = 0.29

p = 0.75

PFC

CNR1

F(1,22) = 0.001

p = 0.98

F(2,22) = 1.41

p = 0.27

F(2,22) = 6.31

p = 0.01

♀0>♂0, p = 0.03

♀0>♀1, p = 0.04

♀0>♀3, p = 0.01

CRHR1

F(1,22) = 1.93

p = 0.18

F(2,22) = 3.25

p = 0.06

F(2,22) = 6.21

p = 0.01

♀0>♂0, p = 0.01

♀0>♀1, p = 0.03

♀0>♀3, p = 0.03

Eno2

F(1,22) = 0.35

p = 0.56

F(2,22) = 1.97

p = 0.27

F(2,22) = 9.15

p = 0.002

♀0>♂0, p = 0.02

♀0>♀1, p = 0.01

♀0>♀3, p = 0.01

♂0<♂3, p = 0.02

♂1<♂3, p = 0.01

GABRA1

F(1,22) = 1.05

p = 0.32

F(2,22) = 3.90

p = 0.04

F(2,22) = 0.17

p = 0.84

GAP43

F(1,22) = 5.26

p = 0.04

♀<♂

F(2,22) = 0.32

p = 0.73

F(2,22) = 0.71

p = 0.51

HIF-1\(\:\alpha\:\)

F(1,22) = 0.32

p = 0.58

F(2,22) = 3.71

p = 0.05

F(2,22) = 0.17

p = 0.84

MapK

F(1,22) = 0.66

p = 0.43

F(2,22) = 2.26

p = 0.14

F(2,22) = 4.97

p = 0.02

MBP

F(1,22) = 5.60

p = 0.03

♀<♂

F(2,22) = 0.48

p = 0.63

F(2,22) = 0.44

p = 0.65

SYP

F(1,22) = 0.04

p = 0.85

F(2,22) = 4.58

p = 0.03

F(2, 22) = 14.13

p < 0.001

♀0>♂0, p = 0.003

♀3<♂3, p < 0.001