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Table 2 List of factors, secretion of which is up- or dawn-regulated in reactive States of microglia and astrocytes

From: Downregulation of STAT3 transcription factor reverses synaptotoxic phenotype of reactive astrocytes associated with prion diseases

Protein

Density

Microglia

Astrocytes

normal

reactive

normal

reactive

ICAM-1

4033 ± 88*

1005 ± 80

1009 ± 5.5

993 ± 58

IL-1a

105 ± 6

4133 ± 145

105 ± 4.4

301 ± 57

IL-1b

200 ± 5.8

2533 ± 260

107 ± 4.7

205 ± 3.8

IL-1ra

103 ± 6.7

3900 ± 295

96 ± 7.2

169 ± 11

IL-6

140 ± 5.4

3511 ± 119

120 ± 2.9

3121 ± 104

IL-12

105 ± 5.8

155 ± 7.6

103 ± 5.8

2047 ± 33

IL-16

3033 ± 202

1993 ± 121

201 ± 15

305 ± 15

CXCL10

121 ± 2.6

1507 ± 57

130 ± 5.8

153 ± 6.1

CXCL12

136 ± 6.0

317 ± 11.9

110 ± 6.2

2200 ± 57

CXCL1

1026 ± 17

4512 ± 261

113 ± 21

2133 ± 88

CCL2

139 ± 5.9

3834 ± 88

135 ± 7.6

1932 ± 33

CCL3

151 ± 10

3153 ± 129

141 ± 4.5

210 ± 11

CCL5

140 ± 5.8

4241 ± 83

121 ± 7.3

216 ± 3.2

CCL12

111 ± 3.7

190 ± 5.6

111 ± 8.7

2217 ± 124

CCL4

210 ± 5.7

234 ± 8.6

131 ± 6.0

1099 ± 57

TNF-a

153 ± 5.5

2111 ± 57

116 ± 2.9

213 ± 2.6

TIMP-1

1007 ± 8.8

1196 ± 98

1003 ± 54

613 ± 40

  1. * Bold font used for secreted factors that were found to be up- or downregulated in reactive states relative to homeostatic states with high statistical significance