Histomorphological variations in progressive multifocal leukoencephalopathy correlated with JCV replication in brain lesions: insights from 91 patients

Table 2 Percentile, median, and geometric means of JCV genome copies in PML brain samples according to underlying diseases

Underlying disease	Hematologic malignancy	Autoimmune disease	AIDS	Solid organ transplantation	Renal dysfunction	Solid organ cancer	Other acquired immunodeficiency	Sarcoidosis	Congenital immunodeficiency	Hepatic dysfunction	Nothing special
Sample number	37	32	16	7	6	5	7	4	2	2	6
25% Percentile	1165	457	45.33	785	100.8	991	0.24	17.68	1090	40.2	30.1
Median	5460	4425	1363	2680	7049	4750	11.6	618.1	1845	13,470	861.4
75% Percentile	18,650	25,800	12,413	6690	53,975	32,250	87	8018	2600	26,900	65,975
10% Percentile	47.3	97.47	12.72	546	40.2	812	0.04	1.54	1090	40.2	10.9
90% Percentile	44,360	97,670	25,910	8600	89,000	10,500	66,800	10,300	2600	26,900	84,500
Geometric mean	2926	3520	666.3	2333	1920	4804	12.38	187.1	1683	1040	724.4
Geometric SD factor	12.34	11.25	18.93	2.883	28.38	5.498	98.95	45.15	1.849	99.53	51.11
Lower 95% CI of geo. mean	1266	1471	139	876.2	57.34	578.7	0.1766	0.4358	6.724	1.164e-015	11.67
Upper 95% CI of geo. mean	6763	8425	3193	6210	64,309	39,878	867	80,372	421,496	9.286e + 020	44,971

ISSN: 2051-5960