Fig. 7

IHC scoring of PML brains and analysis of viral copy numbers and disease progression. a Scoring of IHC in PML brain samples. No specimen reached a score of 4 for agnoprotein (Agno). b IHC scores and JCV copies. VP1 (n = 114), VP2/3 (n = 113), Agno (n = 113), and TAg (n = 114). c IHC scores of Agno + TAg and JCV copies (n = 112). d Relationship between the period from symptom onset to brain sampling and total IHC (VP1 + VP2/3 + Agno + TAg) scores (n = 106). The means with SDs are shown. e PML morphological types and total IHC scores (n = 111). The means with SDs are shown. f IHC score-negative cases and JCV copies in the brain. Geometric means with geometric SDs are shown. Fitted lines are shown with Spearman’s correlation coefficient (rs) in b and c. **p < 0.01