Fig. 5

PML morphological types and JCV copies or histological feature scores. a PML morphological types and JCV copies in dot plots. Biopsy samples (n = 73), autopsy brains (n = 41), and total biopsy and autopsy brains (n = 114) were used. Geometric means with geometric SDs are also shown. b Bubble plots for PML morphological types and histological feature scores of demyelination, enlarged nucleated oligodendroglia, bizarre astrocytes, atypical astrocytes, and foamy macrophage infiltration. Biopsy (n = 74), autopsy (n = 42), and total samples (n = 116) were used. Means with standard deviations (SDs) are shown. The bubble sizes for counts are indicated at the bottom right. c. Schematic illustration of histopathological features with JCV copies and proteins across PML histomorphological types. The lower arrows indicate the lesion location and timing associated with each type