Fig. 2

Quantification of JCV DNA in PML brain tissues. a JCV copies in PML brain tissues. Autopsy and biopsy samples (n = 41 and 74), tissues sampled within 6 months of symptom onset or later (n = 91 and 19), and specimens from patients with each underlying disease were used. Overlapping underlying conditions are counted in each category (total n = 123). Boxes show medians and 25% and 75% percentiles, and whiskers indicate the range from minimum to maximum values. Asterisks indicate significant differences between groups. **p < 0.01. ID: immunodeficiency. b Relationship between the period from symptom onset to brain sampling and JCV copies in the brain (n = 110). Fitted lines are shown with Spearman’s correlation coefficient (rs). **p < 0.01