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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Spatial transcriptomics reveal PI3K-AKT and metabolic alterations in aggressive, treatment-resistant lactotroph pituitary neuroendocrine tumors

Fig. 3

Panel a) Bubble plot of the altered metabolic pathways. Tumors from totally unresponsive patients showed alterations in inositol phosphate, glycerolipid, and pyruvate metabolism. Tumors from partially responsive patients displayed representation of fatty acid elongation, fatty acid degradation and ether lipid metabolism. The metabolism of nucleic acid precursors such as pyrimidine metabolism and pentose phosphate pathways are represented in both lesions. Panels b-i) show the spots with lipid metabolism from the null and partially responsive lesions

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Acta Neuropathologica Communications

ISSN: 2051-5960

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