Fig. 1

Panels a-h) Different cell clusters that comprise tumor mass and the cell deconvolution of each tumor analyzed by spatial transcriptomics. They are organized by their response to pharmacological therapy as completely unresponsive and partially responsive. Tumor complexity increases as response to therapy worsens. Tumor cluster range from 3 to 10 cell clusters. The tumor that was treated primarily with cabergoline showed the lowest number of clusters (a), the partially responsive tumors showed five and eight cell clusters and finally the completely unresponsive tumors showed five, six, seven, eight and ten cell clusters. Tumors are mainly comprised by tumor cells, stem cells, macrophages and endothelial cells, as noted by gene expression deconvolution, H&E analysis and immunohistochemistry