Skip to main content
Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Partial normalization of hippocampal oscillatory activity during sleep in TgF344-AD rats coincides with increased cholinergic synapses at early-plaque stage of Alzheimer’s disease

Fig. 5

Increased number of cholinergic synapses in hippocampus during early-plaque stage. A) Exemplary images of cholinergic synapses (grey) in the CA1 layer of the hippocampus in wildtype littermates (WT) (left) and TgF344-AD rats (Tg) (right) at the pre- and early-plaque stage of AD. B) Group-averaged numbers of cholinergic synapses per region of interest. Bars represent the mean +/- SEM. Dots represent subject MI values. ANOVA analysis was performed to test for statistical differences. If an age*genotype interaction is observed, the results of the post-hoc FDR corrected Students T-test are displayed. DG = dentate gyrus, gen = genotype. ** = p < 0.01 *** = p < 0.001

Back to article page

Acta Neuropathologica Communications

ISSN: 2051-5960

Contact us