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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Partial normalization of hippocampal oscillatory activity during sleep in TgF344-AD rats coincides with increased cholinergic synapses at early-plaque stage of Alzheimer’s disease

Fig. 3

Changes in E/I balance in TgF344-AD rats. A) Exemplary images of the glutamatergic (magenta) and GABA-ergic (yellow) synapses in the CA1 layer of the hippocampus in wildtype littermates (WT) (left) and TgF344-AD rats (right) at the pre- and early-plaque stage. B) Group-averaged vGLUT/vGAT ratio per region of interest. Bars represent the mean +/- SEM. ANOVA analysis was performed to test for statistical differences. DG = dentate gyrus, vGAT = vesicular GABA transporter, vGLUT = vesicular glutamate transporter, E/I = excitatory/inhibitory

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Acta Neuropathologica Communications

ISSN: 2051-5960

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