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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Partial normalization of hippocampal oscillatory activity during sleep in TgF344-AD rats coincides with increased cholinergic synapses at early-plaque stage of Alzheimer’s disease

Fig. 1

Sleep macroarchitecture in TgF344-AD rats. A-C) Percentage time spent in REM (left) NREM (middle) and wake (right) during the total 24-hour acquisition (A) and during the inactive (B) and active phase (C). D-F) Mean NREM (D) and REM (F) bout lengths across 24 h. Bars represent the mean +/- SEM. ANOVA analysis was performed to test for statistical differences. E-G) Cumulative probability plots of NREM bout lengths (E) and REM bout lengths (G) for all animals within each group. The left panel shows the cumulative distribution during the pre-plaque stage, while the right plot shows the early-plaque stage. Kolmogorov-Smirnov tests (FDR p < 0.05) were performed to evaluate if distributions were significantly different. s = seconds, WT = wildtype, Tg = TgF344-AD, * = p < 0.05, ** = p < 0.01, *** = p < 0.001

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Acta Neuropathologica Communications

ISSN: 2051-5960

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