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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Oligodendrocyte-specific overexpression of human alpha-synuclein results in elevated MBP levels and inflammatory responses in TgM83 mice, mimicking the pathological features of multiple system atrophy

Fig. 4

AVOlig001-hSNCA can successfully induce MBP overexpression in TgM83, but not WT. a IF images of MBP signals (orange) in TgM83 + AAVhSNCA mice. The elevated MBP levels was observed on the injection side. Scale bar = 200 μm. b Bar graph showed that MBP was greatly increased in TgM83 + AAVhSNCA, but not in WT + AAVhSNCA mice or when TgM83 + AAVeGFP was injected. c, d Other myelin proteins (MOG and PLP) did not reveal significant difference among all groups. e WB results showed that MBP was increased in the injection side of the TgM83 mice (line 4) (The uncropped gels and blots are available in Supplementary Fig. 1). f The fold change of MBP level between injection and non-injection side in WT + AAVhNSNCA and TgM83 + AAVhSNCA. The relative MBP level increased 1.62 times in TgM83 + AAVhNCA, compared to WT + AAVhSNCA

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Acta Neuropathologica Communications

ISSN: 2051-5960

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