Temporal transcriptomic changes in the THY-Tau22 mouse model of tauopathy display cell type- and sex-specific differences

Table 2 Cell type-specific sex-dependent gene expression changes across major brain cell types in THY-Tau22 mice at 17 months of age

Summary of the most significant differentially expressed genes showing either sex-specific or sex-dimorphic patterns across five major brain cell types. Sex-specific changes indicate significant alterations (FDR < 0.05, absolute log2 fold-change ≥ 0.5) in one sex only (♂: male, ♀: female) with direction shown by arrows (↑: increased, ↓: decreased). Sex-dimorphic changes indicate significant opposing changes between sexes. Notable patterns include widespread male-specific upregulation across cell types, recurrent dysregulation of Malat1 across multiple cell populations, and cell type-specific regulation of genes involved in inflammation (microglia), protein homeostasis (astrocytes), mitochondrial function (neurons), myelination (oligodendrocytes), and vascular function (endothelial cells). All changes compare THY-Tau22 mice to wild-type controls

ISSN: 2051-5960