Temporal transcriptomic changes in the THY-Tau22 mouse model of tauopathy display cell type- and sex-specific differences

Table 1 Most significant sex-dependent differentially expressed genes between THY-Tau22 and wild-type mice at 17 months of age

Type	Gene Symbol	Direction (females)	Direction (males)	FDR Female	FDR Male
Sex-neutral	Fth1	↑	↑	1.97E-09	<2.50E-274
Sex-neutral	Malat1	↓	↓	1.96E-21	<2.50E-274
Sex-neutral	Plp1	↓	↓	5.18E-66	<2.50E-274
Male-specific	Scd2	-	↑	1	<2.50E-274
Male-specific	Trf	-	↑	1	1.09E-19
Male-specific	Zc3h13	-	↑	1	8.00E-16
Female-specific	Hsp90aa1	↑	-	0.0053	1
Sex-dimorphic	Cst3	↓	↑	1.37E-44	<2.50E-274
Sex-dimorphic	Mbp	↓	↑	2.42E-12	<2.50E-274
Sex-dimorphic	Apod	↓	↑	0.00015	9.63E-124

All genes shown exhibited significant expression changes (FDR < 0.05) with absolute log2 fold-change ≥ 0.5 in the sex(es) where they showed significance. Direction refers to expression changes in THY-Tau22 mice compared to wild-type controls (↑: increased, ↓: decreased, -: no significant change). FDR values are adjusted p-values correcting for multiple testing. Sex-neutral genes showed consistent changes in both sexes. Sex-specific genes showed significant changes in only one sex, with no trend toward significance in the other (P > 0.5). Sex-dimorphic genes showed opposing directions of change between sexes, with a minimum difference in log2 fold-change of 0.5

ISSN: 2051-5960