Fig. 9

Gene regulatory network of sex-dimorphic differentially expressed genes in 17-month-old THY-Tau22 mice (global analysis across cell types). Nodes represent genes (red = increased expression, blue = decreased expression); edges show regulatory interactions (green arrows = activation, red lines = inhibition). The network comprises 22 nodes and 49 interactions (26 activations, 14 inhibitions). Key regulatory genes appear in the upper part with downstream targets below