Fig. 12

Gene regulatory network of age-dependent transcriptional changes in microglial cells. Network shows relationships between differentially expressed genes in THY-Tau22 mice between 7 and 17 months of age. Node colors indicate expression changes (red = increased, blue = decreased). Edges show regulatory interactions (arrows = activation, perpendicular lines = inhibition). Only the 16 gene interaction partners of Klf4 with lowest p-values are shown to ensure the interpretability of the network