Fig. 1

Overview of study design and analytical workflow for single cell analyses. Schematic showing the comparison of newly generated data from 17-month-old THY-Tau22 mice (n = 4 male THY-Tau22, n = 4 male wildtype, n = 5 female THY-Tau22, n = 3 female wildtype) with previously published data from 7-month-old mice (n = 5 per group) and data from the Tg2576 mouse model (n = 9 per group) and human AD cortical tissue (n = 3 per group). Green dashed line indicates age-dependent analyses; blue dashed line indicates cross-model comparisons with Tg2576 mice and human AD data. The workflow includes tissue processing, sequencing, data analysis, and comparative analyses