Age-dependent interactions of APOE isoform 4 and Alzheimer’s disease neuropathology: findings from the NACC

Table 1 Definitions and dichotomous criteria for neuropathological variables

Variable Name	Definition	NACC Neuropathology v.10 Variable	Dichotomous Criteria
			0	1
Neuritic plaques	Density of neocortical neuritic plaques (CERAD score) (C score)	NACCNEUR	Absent	Sparse/Inter./Freq
Braak staging	Braak stage for neurofibrillary degeneration (B score)	NACCBRAA	Absent	B1/B2/B3
Diffuse plaques	Density of diffuse plaques (CERAD semiquantitative score)	NACCDIFF	Absent	Sparse/Inter./Freq
LBD pathology	Lewy body pathology derived	NACCLEWY	Absent	Brainstem predominant/limbic (transitional) or amygdala-predominant/neocortical (diffuse)
TDP-43	pTDP-43 in amygdala, hippocampus, entorhinal/inferior temporal cortex, or neocortex	NPTDPB, NPTDPC, NPTDPD, NPTDPE	Absent	Present (any region)
Hippocampal sclerosis	Hippocampal sclerosis (CA1 and/or subiculum)	NPHIPSCL	Absent	Present
Arteriolosclerosis	Arteriolosclerosis	NACCARTE	Absent	Mild/Moderate/Severe
Atherosclerosis of the circle of Willis	Atherosclerosis of the circle of Willis	NACCAVAS	Absent	Mild/Moderate/Severe
CAA	Cerebral amyloid angiopathy	NACCAMY	Absent	Mild/Moderate/Severe
Infarcts/lacunes	Infarcts and lacunes	NACCINF	Absent	Present
Microinfarcts	Microinfarcts	NACCMICR	Absent	Present
Hemorrhages/microbleeds	Hemorrhages and microbleeds	NACCHEM	Absent	Present

NACC National Alzheimer’s Coordinating Center; CERAD Consortium to Establish a Registry for Alzheimer’s Disease; Braak Staging method to classify the severity of neurofibrillary tangles in Alzheimer’s disease; ADNC Alzheimer’s Disease Neuropathologic Change; NIA-AA National Institute on Aging–Alzheimer’s Association; LBD Lewy Body Disease; TDP-43 Transactive Response DNA-binding Protein of 43 kDa; CAA Cerebral Amyloid Angiopathy; CA1 Cornu Ammonis 1 (a region of the hippocampus); inter. Intermediate; Freq. frequent; Mod. Moderate; Sev. Severe
This table outlines key neuropathological variables and their definitions as per the National Alzheimer’s Coordinating Center (NACC) Neuropathology v.10 dataset. Each variable is paired with its corresponding NACC code and categorized into dichotomous criteria. “0” indicates the absence or low levels of pathology, while “1” represents the presence or high levels of pathology, based on standardized scoring systems such as CERAD, Braak staging, and NIA-AA guidelines. This classification aids in evaluating the presence and severity of neuropathological changes associated with Alzheimer’s disease and related conditions

ISSN: 2051-5960