Fig. 3

Adjusted prevalence of neuritic plaques across age groups stratified by APOE ε4 status and sex. Red lines represent individuals with APOE ε4 positivity, while blue lines indicate those without the APOE ε4 allele (APOE ε4 negative). Facets were used for male and female sex. The adjusted prevalence was derived from modified Poisson regression models adjusted for education level and included the interaction term between sex, APOE ε4 and age at death, with robust standard errors applied to account for heteroscedasticity. The line represents the mean adjusted prevalence, and the surrounding band denote 95% confidence intervals calculated from robust standard errors. Abbreviations: APOE ε4 Apolipoprotein E epsilon 4 allele; CI confidence interval