Fig. 4
From: Genomic and immune profiling of breast cancer brain metastases
Differential gene and pathway expression in brain metastases compared to extracranial tumors. a Volcano plot of differentially expressed genes, b Hallmark pathways enriched in FFPE BrM compared to FFPE ECT, and c pathways of interest enriched in paired FFPE BrM-FFPE ECT samples (n = 8 patients). Excluded from analyses were a secondary ECT sample from a single patient and 2 patients with low quality samples and/or other outlier features. Genes were pre-filtered to those with more than five counts in a minimum of 20% of sample libraries per group