Fig. 3
From: Premature skeletal muscle aging in VPS13A deficiency relates to impaired autophagy
Vps13a−/− skeletal muscle metabolomics analysis highlights severe energy stress, impairment of fatty acid metabolism and depletion of phosphor-creatinine pools consistent with muscle wasting. (a) Hierarchical clustering analysis of the top 50 metabolites by unpaired t-test. (b) Volcano plot of muscle metabolites elevated (red) or reduced (blue) in Vps13a-/- vs. WT mice. Dotted axes mark thresholds of statistical significance or log2(FC). (c) (d). Pathway analysis of the most down-regulated (c) or up-regulated pathways (d) in Vps13a-/- vs. control muscle.