Fig. 2

Co-expression of α9 integrin and kindlin-1 promotes sensory axon regeneration. A An example of spinal lesions at T10 from the α9-kindlin group. Many red (α9-V5 stained) axons approach the lesion from the right (caudal). There is some tangled growth as they enter the bridge across the top of the lesion, then the axons re-enter CNS tissue to grow rostrally on the left. Scale bar: 200 μm. B An example of axons passing through a fine connective tissue bridge. At the rostral end (left) there is a region of wandering tangled growth as the axons re-enter CNS tissue. Scale bar: 100 μm. C Where axons reach the point where connective tissue strands interface with CNS tissue, some axons continue to grow in the meninges besides CNS tissue (white arrows). The MRI image on the bottom left shows where the detail came from. Scale bar: 50 μm