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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: VOPP1::EGFR fusion is associated with NFκB pathway activation in a glioneural tumor with histological features of ganglioglioma

Fig. 2

Representative microphotographs of H&E staining show brain parenchyma and a glioneural tumor exhibiting microcystic changes and perivascular lymphoid cuffing. Inset: higher magnification image showing interspersed ganglion cells (asterisks) (A). A neoplastic neuronal component was identified by positivity for NeuN immunohistochemistry (B) and chromogranin A immunohistochemistry (C), whereas the glial tumor component was Olig2 positive (D). Proliferation (Ki-67) was low, approximately 1–2% (E). Multiple CD34-positive stellate cells (asterisks) were identified (F). Scale bar = 100 μm for A and E; for B, D, F, scale bar = 50 μm; for C, F, inset A, and inset F, scale bar = 20 μm

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Acta Neuropathologica Communications

ISSN: 2051-5960

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