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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: IL13RA2-integrated genetically engineered mouse model allows for CAR T cells targeting pediatric high-grade gliomas

Fig. 2

Analysis of GEM models of midline glioma expressing IL13RA2. (A) Visual schematic of RCAS vector generated with PDGFB and IL13RA2 transgenes flanked by recombination att sites used to transfect DF-1 cells. Validation of PDGFB and IL13RA2 expression in DF-1 by (B) flow cytometry and (C) western blot. (D) Comparison of survival for Nestin-Tva; p53fl/fl mice injected at midline location with DF-1 producing virus containing RCAS-CRE and PDGFB or PDGFB + IL13RA2

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Acta Neuropathologica Communications

ISSN: 2051-5960

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