Fig. 1

Dysregulation of primary cilia gene networks in cortical neurons from PD patients. Differentially expressed genes (DEGs) in the prefrontal cortex of PD neurons were identified in our RNAseq dataset using a robust linear regression model a Significantly altered genes in PD cortical neurons are highlighted in orange (q < 0.05, log(FC) ≥ 0.5, robust linear regression, multiple testing corrected). b Number of significantly dysregulated (up- and down-regulated) genes in all PD neurons relative to controls (q < 0.05). c Heatmap of dysregulated primary cilia-associated genes under the ‘ciliopathies’ hub. d Network and clustering of the significantly enriched pathways obtained via GSEA of the transcriptomic changes in PD neurons, with nodes representing altered pathways clustered into networks by EnrichmentMap and node colors constituting normalized enrichment score e, f Enrichment plots for ciliopathies (e) and oxidative phosphorylation (f), g Heatmap of dysregulated pathways in PD neurons as revealed by Cell component and Wiki pathways