Fig. 2
From: PARP inhibition preserves cone photoreceptors in rd2 retina
PARP inhibition prevents photoreceptor cell death in the rd2 retina. TUNEL assay showed a significant decrease in the numbers of positive cells for 100 nM Olaparib, 3 nM BMN-673, and 10 nM 3AB treated groups in the organotypic retinal culture. The most neuroprotective PARP inhibitor was 3 nM BMN-673 (A–D, I, J). The thickness and photoreceptor row number were increased for all three inhibitors (E–H, K, L). The images shown are representative for observations on at least three different specimens for each genotype/treatment condition. n ≥ 3, significance levels: *p < 0.05, **p < 0.01, ***p < 0.001, ****p< 0.0001. ANOVA test and Dunnett’s test for multiple comparisons