Fig. 1
From: PARP inhibition preserves cone photoreceptors in rd2 retina
Treatment schedule of rd2 organotypic retinal culture and PARP inhibition decreases PARylation. A schematic figure of rd2 organotypic retinal culture treatments with Olaparib, BMN-673, and 3AB (A), PAR immunoreactivity in untreated rd2 retinas (B), as well as Olaparib (C), BMN-673 (D), and 3AB (E) treated groups. Scale bar, 50 μm. The plots show the percentages of PAR positive photoreceptors in the outer nuclear layer (ONL) (F). Arrows indicate PARylated photoreceptors. The images shown represent observations on at least three different specimens for each genotype/treatment condition. n ≥ 3, significance levels: *P < 0.05, **P < 0.01, ***P < 0.001. ANOVA testand Kruskal–Wallis test for multi-comparisons