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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Chromogen-based double immunohistochemical detection of mitochondrial respiratory chain deficiencies in human brain tissue

Fig. 2

Mitochondrial respiratory complex staining across brain regions in POLG disease and controls. Representative images show double chromogen immunohistochemical staining for (a) NDUFS4, (b) MTCOI, and (c) SDHA in the prefrontal cortex (PFC), occipital cortex (OC), CA4 region of the hippocampus, and cerebellar cortex (CC) of individuals with POLG-disease. Black arrows indicate neurons negative for MRC complexes I, II, or IV, but positive for VDAC1. Scale bars: 100 μm for PFC, OC, and CA4; 250 μm for CC. (d–f) Scatterplots showing the percentage of neurons positive for (d) NDUFS4, (e) MTCOI, and (f) SDHA in the same brain regions of individuals with POLG-disease (POLG, blue) and controls (Ctrl, orange). Scatterplots show individual values (dots), median and interquartile range

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Acta Neuropathologica Communications

ISSN: 2051-5960

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