Table 1 Univariate analysis of associations of clinical factors with overall survival. P-value was calculated using log rank sum test. Hazard Ratio (HR) > 1 indicates negative correlation with OS.
Feature | # (% or range) | HR (95% CI) | P value |
|---|---|---|---|
Follow-up from initial surgical resection, median (range), months (n = 74) | 7.8 (0.8–132.6) | NA (Outcome Variable) | NA |
Normalized age at initial surgery, median (range), years (n = 69, Unknown = 5) | 54 (26–76) | 1.04 (0.81, 1.34) | 0.741 |
Gender | |||
 Female, n (%)  Male, n (%) | 31 (41. 9%) 43 (58.1%) | 1 (Reference) 1.1 (0.66, 1.82) | 0.718 |
Pre-operative KPS, median (range) (n = 60, Unknown = 14) | 90 (20–100) | 0.98 (0.96, 0.99) | 0.006 |
KPS above 70 | |||
 No, n (%)  Yes, n (%)  Unknown, n (%) | 8 (10.8%) 52 (70.3%) 14 (18.9%) | 1 (Reference) 0.41 (0.19, 0.89) | 0.025 |
Post-operative radiation | |||
 No, n (%)  Yes, n (%) | 39 (52.7%) 35 (47.3%) | 1 (Reference) 1.13 (0.69, 1.87) | 0.627 |
Extent of resection | |||
 Gross Total Resection, n (%)  Subtotal Resection, n (%)  Unknown, n (%) | 52 (70.3%) 9 (12.2%) 13 (17.5%) | 1 (Reference) 0.86 (0.39, 1.92) | 0.72 |
Presence of more than one MBM | |||
 No, n (%)  Yes, n (%)  Unknown, n (%) | 33 (44.6%) 29 (39.2%) 12 (16.2%) | 1 (Reference) 0.79 (0.46, 1.37) | 0.402 |
Presence of Extracranial disease at the time of craniotomy | |||
 No, n (%)  Yes, n (%)  Unknown, n (%) | 19 (25.7%) 52 (70.3%) 3 (4.0%) | 1 (Reference) 2.22 (1.22, 4.03) | 0.008 |
Extracranial stage IV disease status | |||
 Controlled, n (%)  Uncontrolled, n (%)  Unknown, n (%) | 32 (43.2%) 37 (50.0%) 5 (6.68%) | 1 (Reference) 2.13 (1.25, 3.63) | 0.006 |
Serum LDH | |||
 Elevated, n (%)  Not Elevated, n (%) | 17 (28.3%) 43 (71.7%) | 1 (Reference) 0.53 (0.28, 0.98) | 0.042 |