Fig. 1

Differentially expressed pathways in MBM long term survivors (LTS) compared to short-term survivors (STS). A. Schematic of the analysis of MBM LTS versus STS gene expression patterns. For patients with RNA expression data from more than one surgically resected MBM, the earliest resected sample was used for analysis. B. Kaplan–Meier OS curves for LTS (solid line) and STS (dashed line) MBM patients with Hazard ratio (HR) and 95% Confidence interval. Median OS is 22.6 months for the LTS group and 2.6 months for the STS group. C. Analysis of differentially expressed Hallmark pathways demonstrates that inflammatory- and interferon-related gene sets were upregulated (in black), while MYC targets and OXPHOS-related pathways were downregulated (in grey), in LTS compared to STS MBMs. X-axis is Negative Log FDR (False Discovery Rate). D. Boxplot of OXPHOS Index for LTS (circles) vs STS (triangles) MBMs