Fig. 5
From: Cranial radiation disrupts dopaminergic signaling and connectivity in the mammalian brain
Coupling between firing activities in the ventral tegmental area (VTA) and prefrontal cortex (PFC). (A) Segments of local field potentials recorded simultaneously from the PFC and VTA in a free-moving animal, as visualized with an implanted multi-electrode array. (B) The autospectrum of 2-min local field potentials recorded simultaneously from the PFC and VTA. (C) The coherence spectrum between the two recordings. (D) Histograms of Y-maze spontaneous alternation indicated a significant decrease in spontaneous alternation rates in rats 28 days after irradiation, compared to the sham control group (n = 5, two-way ANOVA, F(1,16) = 10.94, P = 0.0045; Sham RT vs. RT on day 28 post irradiation, P = 0.016, *P < 0.05), while there was no statistical significance between groups in the total arm entries (n = 5, two-way ANOVA, F(1,16) = 0.52, P = 0.48)