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Table 3 Clinical, immunohistochemical and molecular features of atypical meningiomas according to their histopathological features

From: Refining prognostic stratification of atypical meningiomas: significance of chromosome 1p deletion and brain invasion

Parameter

Histological group

P

 

Mitotically active

Brain invasive otherwise benign

Only minor atypical criteria

 

Age

    

 ≤ 65 years

38

14

2

0.0298

 > 65 years

24

11

9

Sex

    

 Male

37

13

4

0.335

 Female

25

12

7

Site

    

 Convexity

37

7

2

0.0034

 Parafalcine/tentorial

18

9

8

 Skull base

6

9

1

 Ventricular

1

0

0

Recurrence

    

 Absent

14

12

5

0.0617

 Present

39

11

5

Immunohistochemical group

    

 Group 1 (ACADL-/MCM2-)

12

12

4

0.0328

 Group 2 (ACADL+/MCM2-)

13

5

0

 Group 3 (MCM2+)

37

8

7

NF2 mutation

    

 Absent

9

8

5

0.394

 Present

16

13

3

AKT1 mutation

    

 Absent

25

17

8

0.0336

 Present

0

4

0

1p deletion

    

 Absent

14

13

9

0.0007

 Present

41

12

2