Table 2 Univariate and multivariate analyses for recurrence-free survival in 86 patients with atypical meningioma

Age

 ≤ 65 years

1

0.975

 > 65 years

1 (0.5–1.7)

Sex

 Male

1

0.650

 Female

0.8 (0.5–1.5)

Site

 Convexity

1

0.0021

1

 Parafalcine/tentorial

1.7 (0.9–3.1)

2.1 (1.1–4.1)

0.0177

 Skull base

0.8 (0.4–1.6)

1.7 (0.6–5.1)

0.297

 Ventricular

13 (0-12186)

10 (1.2–97.1)

0.0316

Simpson grade

 1

1

0.452

 2

1.4 (0.7–2.8)

 3

1 (0.3–2.8)

Histological group

 Mitotically active

2.7 (1.5–4.8)

0.0054

1

 Brain invasive otherwise benign

1

0.2 (0.1–0.6)

0.0036

 Minor atypical criteria

1.8 (0.7–4.7)

0.7 (0.2–1.9)

0.539

Immunohistochemical group

 Group 1 (ACADL-/MCM2-)

1

0.0007

0.4 (0.2-1)

0.0689

 Group 2 (ACADL+/MCM2-)

2.5 (1.2–5.2)

0.7 (0.3–1.6)

0.529

 Group 3 (MCM2+)

3.6 (2-6.5)

1

NF2 mutation

 Absent

1

0.794

 Present

0.8 (0.3–2.1)

AKT1 mutation

 Absent

1

0.882

 Present

1.1 (0.2–5.3)

1p deletion

 Absent

1

0.0048

0.4 (0.2–0.9)

0.0290

 Present

2.3 (1.2–4.1)

1

1p deletion/22q deletion

 1pdel/22q non-del

1

0.431

 1p del/22q del

1.7 (0.3–8.8)