Fig. 1

Relative expression levels of IL10 and IL4 family of ligands and receptors in preclinical mouse models of AD and AD. A. Normalized FPKM values of mouse transcripts obtained from different cell types, indicated on bottom, was scaled using z-score. Data was obtained from the Single Cell Portal at Broad Institute. Expression scaling denotes gene expression scaled across all cell types and percent refers to % cells within a specific cell type expressing the gene. B-C. Graphs showing normalized counts of RNA transcripts from different ages (denoted on x-axis) of APP TgCRND8, APP/PS1 Line 85, MAPT rTg4510 and MAPT JNPL3 mice (B) and statistical analysis depicting genotype by age interaction of gene expression (C). Each datapoint, obtained from AMP-AD synapse database, indicates an individual sample. TG, transgenic for human transgene indicated on top panel; NTG, nontransgenic wild type genetic background-matched mice. 1-way Anova, *p < 0.05, **p < 0.01, ***p < 0.001. D. Normalized FPKM values of human transcripts obtained in each cell type, indicated on bottom, was scaled using z-score. Expression scaling denotes gene expression scaled across all cell types and percent refers to % cells within a specific cell type expressing the gene. Data was obtained from CZ CELLxGENE Discover platform. E. Graphs showing normalized counts of RNA transcripts from two different human brain regions collected from Mayo AD cohorts (temporal cortex, TCX and cerebellum, CER) and available from AMP-AD synapse database. Each datapoint indicates an individual sample. 1-way Anova. Patients with different diagnoses indicated on x-axis (Control, healthy non-dementia; AD, Alzheimer’s disease; PSP, Progressive Supranuclear Palsy; PA, Pathologic Aging)