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Table 1 Clinicopathological profile of glioblastoma patients in cohort A and cohort B cohorts

From: Epitranscriptomic analysis reveals clinical and molecular signatures in glioblastoma

 

Cohort A

N = 56 (61%)

Cohort B

n = 36 (39%)

p-value

Effect Size

Diagnostica

     

0.43 2

PD

41

(37.2)

18

(50)

0.04*

 

psPD

15

(37.7)

18

(50)

  

Gendera

      

Male

35

(62.5)

24

(66.6)

0.85

0.04 1

Female

21

(37.5)

12

(33.3)

  

Age (years)b

62

(13.7)

67

(10.0)

0.10

0.17 1

BMIb

27.9

(9.2)

29.1

(8.2)

0.35

0.11 1

Sidec

      

Left

28

(50.0)

21

(58.4)

0.57

0.11 1

Right

28

(50.0)

15

(41.6)

  

Lesion Size (cm)c

4.1

(1.8)

4.0

(2.0)

0.71

0.07 1

Lobe Locationa

     

0.67 2

Frontal

21

(37.5)

8

(22.2)

  

Occipital

0

(0)

5

(13.8)

0.02*

 

Parietal

16

(28.5)

8

(22.2)

  

Temporal

19

(33.9)

15

(41.6)

  

Midline Shifta

     

0.22 2

Yes

23

(41.1)

10

(27.7)

0.28

 

No

33

(58.9)

26

(72.3)

  

Ki-67 Positive Percentb

30.0

(20.0)

27.5

(22.2)

0.24

0.12 1

MGMT Statusa

     

0.13 1

Hypermethylated/ Methylated

23

(41.1)

18

(50.0)

0.53

 

Not Hypermethylated/ Unmethylated

33

(58.9)

18

(50.0)

  

EGFR Amplificationa

     

0.44 2

No

29

(70.7)

19

(59.4)

0.11

 

Yes

12

(29.3)

13

(40.6)

  

P53 Mutation Status (> 10% of Cells)a

     

0.18 1

Negative

11

(22.0)

7

(20.6)

0.68

 

Positive

39

(78.0)

27

(79.4)

  

WBC (Pre-surgery)b

11.2

(6.5)

9.1

(4.6)

0.16

0.14 1

Hemoglobin (Pre-surgery)c

14.1

(2.3)

14.5

(1.8)

0.55

0.06 1

Platelets (Pre-surgery)c

247.8

(71.9)

233.4

(61.1)

0.30

0.21 2

Neutrophils (Segs + Bands) (Pre-surgery)c

9.2

(4.2)

7.8

(4.4)

0.13

0.32 2

Lymphocytes (Pre-surgery)c

1.2

(0.7)

1.4

(0.6)

0.21

0.30 2

Number of Gy administereda

     

0.39 2

40

5

(8.9)

4

(11.1)

1.00

 

60

51

(91.1)

32

(88.9)

  

Number of Gy Fractionsa

     

0.00 1

15

5

(8.9)

4

(11.1)

1.00

 

30

51

(91.1)

32

(88.9)

  

Cycles Completedb

5

(5.0)

5.5

(3.0)

0.69

0.04 1

Adjuvant Temodar Doseb

280

(190.0)

355

(106.2)

0.02*

0.24 2

  1. a n (%), b median (IQR = interquartile range), c mean (SD = standard deviation)
  2. 1 small (≤ 0.2), 2 moderate (= 0.5), 3 large (≥ 0.8)
  3. BMI = Body Mass Index, WBC = White Blood Cell
  4. *p-value significant (p < 0.05) tested using Fisher exact test for Lobe location variable, chi-square for categorical variables, and t-test or Wilcoxon for continuous variables