Fig. 5

Comprehensive insight into differential methylation transcripts. Figure (A) showcases a heatmap depicting the distribution of 87 DMTs among patients. (B) the volcano plot delineates 38 hypomethylated and 49 hypermethylated DMTs. (C) Demonstrates a network diagram featuring key genes (depicted as green circles) with hyper- or hypomethylated status, their gene co-expressions (indicated by red lines), or protein-protein interactions (indicated by purple lines). These genes are associated with the top eight GO pathways (depicted as pink circles) and KEGG pathways (depicted as blue circles). All pathways present p-value < 0.05. Venn diagram showing the hub genes between DMT and (D) Magenta, (E) Purple, and (F) Lightcyan module