Fig. 2

Domain structure of human VAPB, VAPA and PTPIP51 with amino acid numbers indicated (the shorter 249 amino acid VAPA isoform is shown). VAPB and VAPA MSP and coiled-coil domains are shown along with their C-terminal transmembrane ER targeting sequences (TM). PTPIP51 N-terminal transmembrane mitochondrial targeting sequence (TM), coiled-coil domain, FFAT motif (VYFTASS) and C-terminal tetratricopeptide repeat domain are all shown