Fig. 1

Representative EM images of ER-mitochondria contact sites in a control transfected NSC-34 motor neuron cell (left) and in an NSC-34 cell transfected with both VAPB and PTPIP51 (right). VAPB and PTPIP51 transfection dramatically increases ER − mitochondria contacts (see orange loops) and high magnification images reveal the presence of structures connecting the two organelles which may correspond to VAPB-PTPIP51 tethers (see red arrowheads)