Locus coeruleus tau validates and informs high-resolution MRI in aging and at earliest Alzheimer’s pathology stages

Table 1 Demographic information for all (n = 21) samples

Sample	Age (years)	Sex	Hemisphere	BB stage	PMI (hours)	Brain weight (grams)	MRI resolution (μm³)
1	49	M	LH	0	3	1300	–
2	52	F	LH	0	15	1250	120
3	58	M	RH	0	25	1154	150
4	61	M	RH	0	23	1310	120
5	61	M	RH	0	159	1325	120
6	63	M	LH	0	< 12	1359	120
7	64	M	RH	0	15	1230	–
8	65	M	LH	0	25	1309	–
9	68	M	RH	0	17	1320	100
10	59	M	LH	I	20	1319	150
11	68	M	RH	I	< 24	1595	100
12	72	F	RH	I	105	1400	–
13	73	F	RH	I	23	1356	150
14	79	M	LH	I	15	1200	150
15	60	F	LH	II	2	1328	150
16	60	F	LH	II	n/a	> 1380	–
17	62	M	LH	II	16	1370	150
18	75	M	LH	II	24	1187	120
19	78	M	LH	II	24	1320	100
20	70	M	LH	III	24	1250	200
21	77	F	LH	III	34	1300	120

Samples include a subset with both histological validation and ex vivo high-resolution MRI scans (n = 11). Five LC samples had only MRI data (#6, 10, 14, 17, and 19) and five had only histology data (#1, 7, 8, 12, and 16). Samples have been ordered by age and diagnosis. All samples were cognitive controls at the time of death
Abbreviations: F = female, M = male, MRI = ex vivo MRI, RH = right hemisphere, LH = left hemisphere

ISSN: 2051-5960