Fig. 5

Tau burden in locus coeruleus at earliest Braak and Braak stages. a Heatmap of mean LC tau severity scores at each rostrocaudal sublevel. Panels b and c show median semi-quantitative tau burden by Braak stage (b; significant differences between BB 0 and BB I vs. BB II, p < 0.0001, Dunn’s multiple comparison test) and sublevel (c) for preclinical (BB 0-II) samples. Plus ( +) symbols indicate mean