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Table 2 Immune cell densities and entropy values (raw values)

From: Density and entropy of immune cells within the tumor microenvironment of primary tumors and matched brain metastases

 

TAMs

TILs

 

Cell densities [cell/mm2]

CD68

CD163

CD3

CD8

FOXP3

CD45RO

  

Overall

Primary

median

866.0

443.9

589.3

207.4

162.9

361.2

  

range

3.8-7738.9

51.1-1785.5

2.5-6037.9

2.3-9005.4

2.2-

1222.3

8.3-

7449.2

   

BM

median

1081.0

810.9

62.7

33.4

68.9

282.8

   

range

79.3–9261.0

14.3-5109.6

0.4-

2322.3

0.0-1758.5

1.5-

2480.7

2.6-

5341.1

  

NSCLC

Primary

median

866.0

472.5

639.8

1989.0

165.7

439.4

  

range

3.8-

6417.6

65.7-

1785.5

26.7-

2347.9

10.5-

1516.8

13.0-

1021.2

8.8-

2747.0

   

BM

median

1047.5

775.9

66.4

26.3

66.9

344.1

  

range

79.3-

9261.0

14.3-

2879.8

0.5-

2322.3

0.5-

1486.2

1.5-

2480.7

2.6-

5341.1

  

BC

Primary

median

306.3

300.6

360.7

388.0

151.1

160.0

  

range

98.9-

7738.9

51.1-

1359.1

2.5-

6037.9

2.3-

9005.4

2.2-

1222.3

8.3-

7449.2

   

BM

median

961.5

978.7

22.6

32.2

55.2

93.2

  

range

237.6-

4483.2

155.6-

2752.5

5.8-

158.9

1.6-

135.4

5.7-

1757.4

6.7-

1917.5

  

RCC

Primary

median

1613.4

575.3

490.1

540.2

76.0

142.4

  

range

425.7-

2163.8

238.3-

988.7

72.3-

1374.1

69.2-

2206.0

11.9-

945.5

43.0-

671.1

   

BM

median

1928.8

1468.0

181.9

169.2

92.8

199.8

  

range

871.3-

5520.9

447.6-

5109.6

11.4-

1441.6

0.0-

1758.5

6.3-

673.4

49.9-

2470.4

 

Shannon Entropy [index]

CD68

CD163

CD3

CD8

FOXP3

CD45RO

  

Overall

Primary

median

0.43

0.51

0.42

0.24

0.34

0.34

  

range

0.0–1.0

0.12–0.77

0.11-1.0

0.0–1.0

0.00–1.0

0.06–0.81

   

BM

median

0.44

0.67

0.31

0.19

0.27

0.38

   

range

0.09–0.82

0.0–1.0

0.0-0.92

0.0-0.66

0.0–1.0

0.0–1.0

  

NSCLC

Primary

median

0.45

0.53

0.42

0.23

0.36

0.35

  

range

0.11–0.8

0.32–0.77

0.11–0.7

0.0-0.49

0.12–0.64

0.07–0.81

   

BM

median

0.46

0.70

0.34

0.19

0.27

0.38

  

range

0.09–0.8

0.0-0.94

0.0-0.92

0.05–0.66

0.0–1.0

0.0–1.0

  

BC

Primary

median

0.23

0.4

0.37

0.25

0.28

0.33

  

range

0.0–1.0

0.12–0.67

0.15-1.0

0.0–1.0

0.0–1.0

0.06–0.65

   

BM

median

0.31

0.17

0.27

0.15

0.27

0.35

  

range

0.09–0.62

0.0-0.79

0.05–0.5

0.08–0.25

0.12–0.87

0.01–0.68

  

RCC

Primary

median

0.42

0.48

0.56

0.36

0.17

0.18

  

range

0.11–0.62

0.32–0.59

0.31–0.72

0.14–0.59

0.08–0.52

0.1–0.43

   

BM

median

0.37

0.63

0.37

0.25

0.25

0.31

  

range

0.26–0.82

0.54-1.0

0.3–0.74

0.0-0.5

0.1–0.38

0.11–0.72

  1. BC: breast cancer, RCC: renal cell carcinoma, TAMs: Tumor-associated macrophages, TILs: Tumor-infiltrating lymphocytes
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Acta Neuropathologica Communications

ISSN: 2051-5960

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