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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Density and entropy of immune cells within the tumor microenvironment of primary tumors and matched brain metastases

Fig. 4

Differences in immune cell entropies between primary tumor and matched brain metastasis (BM). Boxplots indicating significantly higher entropy values of (a) CD3 + TILs (total TCR + lymphocytes; p < 0.001) and (f) FOXP3 + regulatory T cells (Tregs) in primary tumors compared to brain metastasis (BM; p = 0.011). No significant differences were found in (b) CD8 + cytotoxic TILs (CD8 + T lymphocytes), (c) CD45RO + memory T cells, (d) CD68 + TAMs (pan-macrophages) or (e) CD163 + M2-like TAMs (alternatively activated macrophages) (all p > 0.05). ***p < 0.001; **p < 0.01; *p < 0.05; ns . non significant

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Acta Neuropathologica Communications

ISSN: 2051-5960

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