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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Density and entropy of immune cells within the tumor microenvironment of primary tumors and matched brain metastases

Fig. 3

Differences in immune cell densities between primary tumor and matched brain metastasis (BM). Boxplots indicating significantly higher cell densities [cells/mm2] of (a) CD3 + TILs (total TCR + lymphocytes; p < 0.001) and (b) CD8 + cytotoxic TILs (CD8 + T lymphocytes; p < 0.001) in primary tumors compared to brain metastasis (BM). Significantly higher cell densities were found in BM compared to primary tumors regarding (d) CD68 + TAMs (pan-macrophages; p = 0.035) and (e) CD163 + M2-like TAMs (alternatively activated macrophages; p < 0.001). No significant differences were found in (c) CD45RO + memory T cells (p = 0.3) and (f) FOXP3 + regulatory T cells (Tregs, p = 0.377). ***p < 0.001; **p < 0.01; *p < 0.05; ns . non significant

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Acta Neuropathologica Communications

ISSN: 2051-5960

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