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Table 2 Linear mixed-model effects estimate of the effect of time on the thickness of ganglion cell-inner plexiform complex (GCIPL)

From: Dynamics of retinal changes in early-stage Parkinson’s disease

 

PD

Control

Time x group interaction

βa

SE

p

βa

SE

p1

βb

SE

p

GCIPL 1-mm disc

0.38

0.33

0.258

-0.22

0.23

0.334

0.38

0.34

0.274

GCIPL 1- to 2-mm

-0.21

0.33

0.536

-0.19

0.24

0.447

0.02

0.36

0.956

GCIPL 2- to 3-mm

-1.10

0.24

< 0.001 ***

-0.18

0.20

0.384

-0.61

0.29

0.039 *

GCIPL 3- to 4-mm

-1.00

0.26

< 0.001 ***

-0.23

0.21

0.293

-0.60

0.30

0.052

GCIPL 4- to 5-mm

-0.88

0.24

0.001 **

-0.27

0.17

0.116

-0.45

0.26

0.094

GCIPL 5- to 6-mm

-0.90

0.20

< 0.001 ***

-0.30

0.19

0.130

-0.35

0.27

0.204

  1. βa represents the within-group estimated annualized change in thickness within each group per GCIPL region, whereas βb represents the estimated increase or decrease in the annualized change in thickness in PD patients compared to controls. All models were adjusted for age at baseline, sex and hypertension status. Analyses within the PD group were further adjusted for LEDD. Time indicates the time since baseline visit. Significant p-values are represented with an asterisk (* p < 0.05; ** p < 0.01; *** p < 0.001). Abbreviations: GCIPL, ganglion cell-inner plexiform complex; PD, Parkinson’s disease; SE, standard error