Acta Neuropathologica Communications

Table 3 Correlations between RGC parameters and the cognitive status

From: Retinal ganglion cell vulnerability to pathogenic tau in Alzheimer’s disease

	CDR (score)		MMSE (score)
	N = 13–22		N = 10–18
	r_S	P	r_S	P
RBPMS⁺RGCs (count)
Total	-0.33	0.13	0.26	0.31
Central	-0.06	0.83	0.15	0.59
Mid-periphery	-0.43	0.056	0.46	0.065
Far- periphery	-0.51	0.016*	0.32	0.20
Nissl⁺in GCL (% area)
Total	-0.40	0.080	0.48	0.070
Central	-0.52	0.041*	0.28	0.35
Mid-periphery	-0.35	0.13	0.58*	0.024*
Far-periphery	-0.34	0.16	0.64*	0.012*
pS396-tau⁺RGCs (count)
Total	0.65	0.0011**	-0.68	0.0034**
Central	0.61	0.011*	-0.62	0.015*
Mid-periphery	0.63	0.0030**	-0.58	0.017*
Far-periphery	0.65	0.0011**	-0.54	0.026*
Oligo-tau⁺RGCs (count)
Total	0.69	0.0005***	-0.69	0.0039**
Central	0.68	0.0096**	-0.67	0.028*
Mid-periphery	0.64	0.0042**	-0.79	0.0019**
Far-periphery	0.39	0.0837	-0.41	0.1180

Spearman’s rank correlation analyses: P and r_S -values determine the statistical significance and strength of each pairwise association between retinal RGC marker and the cognitive function score. P and r_S -values presented in bold type with asterisk(s) are statistically significant (< 0.05). CDR, Clinical Dementia Rating; MMSE, Mini-Mental State Examination

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