Table 1 Demographic and neuropathological data on human brain and retinal donors in this study

Retinal samples (N = 41)

16

10 F (63%) 6 M

10

7 F (70%) 3 M

15

8 F (53%) 7 M

-

-

Age at death (years)

80.5 ± 11.1

88.4 ± 6.6

87.5 ± 8.0

2.93

0.07

Race

14 W, 1 H, 1B

8 W, 1B, 1 H

12 W, 2 H, 1 A

-

-

PMI (h)

7.8 ± 4.5

10.1 ± 5.4

8.8 ± 4.5

0.5

0.73

MMSE score (N = 30)

28.7 ± 2.1

20.1 ± 7.0

13.8 ± 7.3

17.01

< 0.0001

CDR score (N = 31)

0.57 ± 0.8

2.1 ± 1.1

2.5 ± 0.9

10.53

0.0004

Brain neuropathology (N = 32)

Braak stage (%)

0-II (57%)

III-IV (43%)

V-VI (0%)

0-II (30%)

III-IV (30%)

V-VI (40%)

0-II (0%)

III-IV (13%)

V-VI (87%)

15.2

< 0.0001

ABC average

1.37 ± 0.91

2.20 ± 0.59

2.82 ± 0.21

17.13

< 0.0001

Aβ plaque (severity score)

1.12 ± 1.31

1.88 ± 0.79

2.65 ± 0.77

6.98

0.0034

NFTs (severity score)

0.43 ± 0.53

1.71 ± 0.91

2.36 ± 0.70

16.06

< 0.0001

NTs (severity score)

0.49 ± 0.99

1.24 ± 0.82

1.69 ± 0.90

4.27

0.024