Fig. 8
From: Human induced pluripotent stem cell-derived myotubes to model inclusion body myositis
Mitochondrial profile in IBM vs. CTL iPSC-derived myotubes. A Mitochondrial respiration is represented by kinetics, basal respiration, ATP production, H + leak, coupling efficiency, maximal respiration, and spare respiratory capacity in IBM vs. CTLs. B Total antioxidant capacity (TAC) and lactate secretion in IBM vs. CTLs. C Citrate synthase (CS) activity, cytochrome c oxidase activity (COX) and COX/CS ratio. Mitochondrial respiration and TAC were conserved between cohorts, but lactate and COX/CS were reduced in IBM iPSC-myotubes displaying mitochondrial dysfunction