Table 1 Co-detection by indexing (CODEX) multiplex immunofluorescence of the liver and cerebellar tumors

Tumor cell density

2476.6 per mm²

2700.1 per mm²

Blood vessel density

124.9 per mm²

118.4 per mm²

Expression on tumor cells:

Ki-67

Synaptophysin

CD56

CA9

Pan-CK

CD10

PD-L1

38.3%

0%

46.9%

77%

84.5%

29.4%

20%

51.8%

1.9%

13.9%

23.7%

3.5%

4.4%

0.6%

M2 macrophages

68.4%

58.5%

M1/M2 macrophage ratio

0.46

0.7

CD4⁺FOXP3⁺/CD4⁺ ratio

0.12

0.03

CD4⁺FOXP3⁺ cell density

37.4 per mm²

9.5 per mm²

CD8⁺/CD3⁺ proportion

61.1%

25.8%

CD8⁺ cell density

495.5 per mm²

93.7 per mm²

PD-L1 on immune cells

7.3%

11.4%

PD-L1⁺ M1 macrophages

13.3%

5%

PD-L1⁺ M2 macrophages

8.4%

7.5%

Proliferating CD8⁺PD-L1⁻ cells

19.4%

30.4%

Proliferating CD8⁺PD-L1⁺ cells

20%

76%

CD4⁺PD-L1⁺ cells

3%

3.3%